Activated charcoal should be used to absorb the excess amount of ibuprofen into the body. In the case of ibuprofen poisoning, the stomach should be emptied by lavage or vomiting. Methionine should only be used within 10 hours after taking paracetamol overdose. Methionine is given orally as 2.5 g in every 4 hours interval up to 10 g. route) for 15 minutes, which is followed by intravenous infusion of 50 mg/kg or 22.7 mg/lb of acetylcysteine in 500 ml 5% glucose for 4 hours and 100 mg/kg or 45.45 mg/lb of acetylcysteine in 1 litre 5% glucose for 16 hours. Initially 150 mg/kg or 68.18 mg/lb of acetylcysteine in 200 ml 5% glucose is given through blood veins (intravenous or I. Acetylcysteine should be used within 8 hours of taking paracetamol overdose. For reversing the liver injury antidote therapy of acetylcysteine and methionine should be used as soon as possible. In the case of paracetamol poisoning, immediate medical treatment is given to overcome the risk of liver injury and emptying of the stomach (gastric lavage) should also be considered.
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